Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
TARGETMOL CHEMICALS INC Atecegatran TFA 1MG
Also available in 5 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Atecegatran TFA is often used as an anticoagulant and can be used to treat cardiovascular disease. Purity 98.5%
Medchemexpress LLC Reltecimod TFA | 1447799-33-8 | ≥98% | 1037.19 | 25 MG
Reltecimod TFA is a T cell-specific surface glycoprotein CD28 (TP44) antagonist. It demonstrates good resistance to various bacterial infections, bacterial exotoxins and endotoxins, and ionizing radiation. Reltecimod TFA modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 costimulatory pathway without inhibiting it. It may be used to study necrotizing soft tissue infections (NSTIs).
- T cell-specific surface glycoprotein CD28 (TP44) antagonist
- Good resistance to different bacterial infections, bacterial exotoxins and endotoxins, and ionizing radiation
- Modulates inflammatory response by attenuating the CD28/B7-2 costimulatory pathway
- May be utilized to study necrotizing soft tissue infections (NSTIs)
- Increases survival rate of mice harboring several bacterial infections (at 1.25-5 mg/kg; iv)
Medchemexpress LLC CCZ01048 TFA | 98.5% | 1622.75 | 5 MG
CCZ01048 TFA is an α-MSH analogue that exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. It shows rapid internalization into B16F10 melanoma cells and demonstrates high in vivo stability, making it a promising candidate for PET imaging of malignant melanoma.
- α-MSH analogue
- High binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM
- Rapid internalization into B16F10 melanoma cells
- High in vivo stability
- Promising candidate for PET imaging of malignant melanoma
Medchemexpress LLC LY117018 TFA 5mg | 2390041-98-0 | 573.58 | C29H26F3NO6S | 5 MG
LY117018 TFA is the trifluoroacetic acid salt of LY117018, a raloxifene analog and selective estrogen receptor modulator reported to exert antiproliferative effects on breast cancer cell lines. It is provided as a research reagent for in vitro and in vivo studies of estrogen receptor signaling and related pathways.
- Selective estrogen receptor modulator with reported antiproliferative activity.
- Soluble in DMSO up to 100 mg/mL; sonication may be required.
- In vivo formulations reported with solubility ≈5 mg/mL using common co-solvent systems.
- Recommended storage: solid sealed and kept away from moisture; in solution store at -80°C (up to 6 months) or -20°C (up to 1 month).
- Molecular formula C29H26F3NO6S; molecular weight 573.58.
Medchemexpress LLC GRL-1720 TFA | 2835511-03-8 | C16H12ClF3N2O4 | 5 MG
GRL-1720 TFA is a potent inhibitor of SARS-CoV-2 Mpro, exhibiting anti-SARS-CoV2 activity with an EC50 value of 15 μM. This compound has a molecular weight of 388.73 and appears as a solid, ranging from light brown to brown in color.
- High purity of 98.94%.
- Shipped at room temperature.
- Store at -20°C, sealed, away from moisture.
- In solution, stable for 6 months at -80°C or 1 month at -20°C with sealed storage, away from moisture.
Medchemexpress LLC DV1 TFA | 98.5% | 2424.85 | 5 MG
DV1 TFA is a selective antagonist for CXC chemokine receptor 4 (CXCR4) and exhibits antiviral activity. This product is for research use only and has not been fully validated for medical applications.
- Selective antagonist for CXC chemokine receptor 4 (CXCR4)
- Exhibits antiviral activity
- For research use only
Medchemexpress LLC WP9QY (TFA) | 98.7% | 1340.40 | 500 UG
WP9QY TFA is a biologically active cyclic peptide that acts as a TNF-α antagonist. It is designed to mimic the critical tumor necrosis factor (TNF) recognition loop on TNF receptor I, thereby preventing interactions between TNF and its receptor. This TNF antagonist serves as a useful template for developing small molecular inhibitors to prevent inflammatory bone destruction and systemic bone loss in rheumatoid arthritis. This product is for research use only.
- Biologically active peptide
- TNF-α antagonist
- Mimics TNF recognition loop on TNF receptor I
- Prevents interactions of TNF with its receptor
- Useful for developing small molecular inhibitors
- Prevents inflammatory bone destruction in rheumatoid arthritis
- Prevents systemic bone loss in rheumatoid arthritis
Medchemexpress LLC Cef20 TFA | 99.3% | 1057.19 | 5 MG
CEF20 TFA is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503). It is for research use only.
- An HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503)
- For research use only
Medchemexpress LLC D-GsMTx4 TFA | 99.89% | 4095.84 | 2 MG
D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4. It inhibits the mechanosensitive ion channel Piezo2, [Ca2+]i elevation, and mTOR and PI3K-Akt signaling pathways. This peptide can be used in research related to mechanical stress, chronic pain, and idiopathic pulmonary fibrosis.
- Inhibits Piezo2-mediated mechanosensitive inward currents
- Decreases phosphorylation levels in mTOR and PI3K-Akt signaling pathways
- Inhibits mechanical stimulation-evoked [Ca2+]i increases
- Significantly inhibits mechanical allodynia and thermal hyperalgesia