Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Spexin (Neuropeptide Q) | 1370290-58-6 | >99.9% | 1619.88 | 5 MG
Spexin (Neuropeptide Q) | 1370290-58-6 | >99.9% | 1619.88 | 5 MG
Medchemexpress LLC QL47B TFA | 96.0% | 992.07 | 5 MG
QL47B TFA is a biotinylated analogue of QL47 (HY-80003), functioning as a potent inhibitor of BTK with an IC50 value of 1.3 μM. It also exhibits anti-tumor activity.
- Potent inhibitor of BTK (IC50 value of 1.3 μM).
- Exhibits anti-tumor activity.
Medchemexpress LLC Clovibactin TFA | 97.1% | 903.08 | 1 MG
Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027), serving as an antibiotic for drug-resistant bacterial pathogens without detectable resistance. It functions by inhibiting cell wall synthesis, specifically targeting pyrophosphate of peptidoglycan precursors.
- Effective against drug-resistant bacterial pathogens.
- No detectable resistance observed.
- Inhibits cell wall synthesis through a specific mechanism targeting peptidoglycan precursors.
- Demonstrates inhibition of Staphylococcus strains with MICs ranging from 0.125-2 μg/mL in vitro.
- Exhibits a characterized pharmacokinetic profile in mice, including a Cmax of 219.3 μg/mL and a t1/2 of 2 hours following a 20 mg/kg intravenous single dose.
Medchemexpress LLC Alpha-Melanocyte-Stimulating Hormone TFA | 171869-93-5 | 98.5% | 1 MG
α-MSH TFA (α-Melanocyte-Stimulating Hormone TFA) is an endogenous neuropeptide and a melanocortin receptor 4 (MC4R) agonist. It exhibits anti-inflammatory and antipyretic activities and is a post-translational derivative of pro-opiomelanocortin (POMC).
- Endogenous neuropeptide
- MC4R agonist with anti-inflammatory and antipyretic activities
- Post-translational derivative of pro-opiomelanocortin (POMC)
- Modulates CNS inflammation by acting directly on melanocortin receptors in glial cells
- Modulates NFκB activation
- Inhibits translocation of transcription factor κB to the nucleus
Medchemexpress LLC GpTx-1 TFA | 99.6% | 4073.82 (free base) | 1 MG
GpTx-1 TFA is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM. It also exhibits excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM), demonstrating >20-fold and >950-fold selectivity, respectively. This product is for research use only.
- Potent inhibitory activity against NaV1.7 channel with an IC50 value of 10 nM.
- Exhibits >20-fold selectivity for NaV1.4 (IC50 = 0.301 μM).
- Exhibits >950-fold selectivity for NaV1.5 (IC50 = 4.20 μM).
- Isolated from the venom of the Chilean spider Grammostola porter.
Medchemexpress LLC GIP, rat TFA | 99.8% | 5002.58 | 500 UG
GIP, rat TFA is a bioactive peptide of rat origin, also known as glucose-dependent insulinotropic polypeptide or gastric inhibitory polypeptide. This 42-amino acid peptide is released by K cells in the duodenum and jejunum in response to food intake. As a member of the insulinotropic hormone peptide family, it stimulates insulin secretion from pancreatic beta cells and appears to promote beta cell proliferation and survival. Recent studies suggest that GIP plays a role in lipid homeostasis and may be involved in the pathogenesis of obesity. It is for research use only.
- Bioactive peptide of rat origin
- 42-amino acid peptide
- Stimulates insulin secretion from pancreatic beta cells
- Promotes beta cell proliferation and survival
- Involved in lipid homeostasis and obesity pathogenesis (potential)
- For research use only
Medchemexpress LLC Calcitonin, eel TFA | 99.9% | 3528.89 | 5 MG
Calcitonin, eel TFA is a thyroid hormone peptide that plays a role in regulating calcium homeostasis. It is frequently used in research concerning postmenopausal osteoporosis. In vitro studies show that Calcitonin, eel stimulates phosphoinositide hydrolysis and prolactin release in cultured anterior pituitary cells more effectively than salmon calcitonin. However, it does not inhibit prolactin release under conditions stimulated by thyrotropin releasing hormone (TRH).
- Contributes to the regulation of calcium homeostasis.
- Widely used in postmenopausal osteoporosis research.
- Effectively induces a concentration-dependent stimulation of phosphoinositide hydrolysis in vitro.
- Stimulates prolactin release in cultured anterior pituitary cells in vitro.
- High purity of 99.91%.
Medchemexpress LLC MS9427 TFA | 98.4% | 1107.50 | 5 MG
MS9427 TFA is a potent PROTAC EGFR degrader that selectively targets and degrades mutant EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. This compound effectively inhibits the proliferation of NSCLC cells and shows antiproliferative activity against HCC-827 cells.
- Potent PROTAC EGFR degrader
- Selectively degrades mutant EGFR
- Utilizes ubiquitin/proteoteasome system and autophagy/lysosome pathways
- Inhibits proliferation of non-small cell lung cancer (NSCLC) cells
- Exhibits antiproliferative activity against HCC-827 cells
- Induces EGFRDel19 degradation
Medchemexpress LLC WP9QY (TFA) | 199999-60-5 | 98.7% | 1340.40 | 25 MG
WP9QY TFA is a biologically active cyclic peptide, serving as a TNF-α Antagonist. It is designed to mimic the critical tumor necrosis factor (TNF) recognition loop on TNF receptor I, preventing interactions of TNF with its receptor. This peptide is a useful template for developing small molecular inhibitors to prevent inflammatory bone destruction and systemic bone loss in rheumatoid arthritis. It is for research use only.
- Biologically active peptide
- TNF-α antagonist
- Mimics critical tumor necrosis factor recognition loop on TNF receptor I
- Prevents TNF interactions with its receptor
- Useful template for small molecular inhibitor development
- Prevents inflammatory bone destruction
- Prevents systemic bone loss in rheumatoid arthritis
- For research use only
Medchemexpress LLC Cef20 TFA | 99.3% | 1057.19 | 5 MG
CEF20 TFA is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503). It is for research use only.
- An HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503)
- For research use only
Medchemexpress LLC GRL-1720 TFA | 2835511-03-8 | C16H12ClF3N2O4 | 25 MG
GRL-1720 TFA is a potent inhibitor of SARS-CoV-2 Mpro with an EC50 value of 15 μM, demonstrating anti-SARS-CoV2 activity. This product appears as a light brown to brown solid with a purity of 98.94% and is intended for research use only.
- Potent inhibitor of SARS-CoV-2 Mpro
- Demonstrates anti-SARS-CoV2 activity
- EC50 value of 15 μM
- Solid appearance
- Light brown to brown color
- Purity of 98.94%
- Intended for research use only
FUJIFILM Biosciences Trifluoroacetic Acid Solution (for Gradient Elution) | 76-05-1 | MFCD00004169 | 40mL
Trifluoroacetic Acid Solution (for Gradient Elution) | Putity: 25% | MW: 114.022 | 76-05-1 | MFCD00004169 | 40mL
Medchemexpress LLC Mtvkpabc-p5 TFA | 98.8% | 1190.22 | C54H74F3N11O16 | 25 MG
MTvkPABC-P5 TFA is the trifluoroacetic acid (TFA) salt of a synthetic Toll-like receptor 7 (TLR7) agonist. It functions as an immune stimulant used in research applications, including the synthesis of immune-stimulating antibody conjugates (ISACs).
- Acts as a TLR7 agonist and immune stimulant.
- Suitable for synthesis of immune-stimulating antibody conjugates (ISACs).
- Provided as a solid TFA salt.
- High purity, 98.8%.
- Molecular weight 1190.22, formula C54H74F3N11O16.
- Available as 25 MG quantity.
Medchemexpress LLC PSMA I&S TFA | 98.15% | 1413.43 | 5 MG
PSMA I&S (TFA) is a precursor of the 99mTc-labeled PSMA-targeting ligand, intended for research use only.
- Precursor of 99mTc-labeled PSMA-targeting ligand
- For research use only
Medchemexpress LLC Cilengitide TFA | 199807-35-7 | 99.9% | 702.68 | 25 MG
Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50 values of 4 nM and 79 nM, respectively. It inhibits integrin-mediated binding to vitronectin.
- Potent and selective integrin inhibitor
- Targets αvβ3 receptor with IC50 of 4 nM
- Targets αvβ5 receptor with IC50 of 79 nM