Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC DOTA-ADIBO TFA | 1374865-01-6 | 99.1% | 776.76 g/mol | C36H43F3N6O10 | 5 MG
DOTA-ADIBO TFA is a DOTA-derived bifunctional chelator supplied as the trifluoroacetic acid salt. It enables biomolecule conjugation via strain-promoted, copper-free azide-alkyne cycloaddition and supports construction of fusion chelator systems for radiometal labeling and PET radiotracer synthesis. The compound is provided as a high-purity solid with DMSO solubility and requires protected, low-temperature storage.
- DOTA-derived bifunctional chelator for copper-free click conjugation.
- Facilitates radiometal labeling for PET radiotracer synthesis.
- High reported purity suitable for research applications.
- Soluble in DMSO (≈100 mg/mL); may require sonication.
- Store under nitrogen, protect from light, keep at low temperatures.
- Provided as a TFA salt to aid handling and stability.
Medchemexpress LLC MIP-1095 (TFA) | 99.8% | 678.35 | 25 MG
MIP-1095 TFA (RPS-001 TFA) is a potent inhibitor of PSMA, demonstrating good biodistribution and efficient targeting of tumor lesions. It is utilized as an imaging probe to identify and monitor tumor progression, particularly when isotopically labeled with 131I. This labeling results in 131I-MIP-1095 showing higher renal uptake in mice.
- Potent inhibitor of PSMA
- Good biodistribution
- Efficient targeting of tumor lesions
- Can be isotopically labeled as an imaging probe
- Higher renal uptake in mice when labeled with 131I
- Used as an imaging probe to indicate tumor progression
Medchemexpress LLC Kisspeptin 13 TFA | 98.9% | 1626.81 | 1 MG
Kisspeptin 13 TFA is the TFA salt form of Kisspeptin 13 (HY-P3641). It inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 TFA activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. This compound interacts with α2-adrenergic and 5-HT2 serotonin receptors and exhibits antidepressant efficacy. It is an activator for GPR54 and GnRH receptor, enhancing memory and being useful in Alzheimer's disease research.
- Inhibits glucose-induced insulin secretion (IC50 of 1.2 nM)
- Activates hypothalamic-pituitary-adrenal (HPA) axis
- Causes hyperthermia, motor behavior and anxiety in rats
- Interacts with α2-adrenergic and 5-HT2 serotonin receptors
- Exhibits antidepressant efficacy
- Activator for GPR54 and GnRH receptor
- Enhances memory
- Useful in Alzheimer's disease research
Medchemexpress LLC Liraglutide TFA | 204656-20-2 | 99.6% | 3751.20 (free base) | 1 MG
Liraglutide (TFA) is an agonist of glucagon-like peptide 1 receptor (GLP-1). It can activate GLP-1, leading to insulin release in the presence of increased glucose concentration, and also reduces glucagon secretion in a glucose-dependent manner. It can be used in research on type 2 diabetes.
- Activates GLP-1 receptor
- Leads to insulin release
- Reduces glucagon secretion
- Suitable for type 2 diabetes research
Medchemexpress LLC WP9QY (TFA) | 98.7% | 1340.40 | 500 UG
WP9QY TFA is a biologically active cyclic peptide that acts as a TNF-α antagonist. It is designed to mimic the critical tumor necrosis factor (TNF) recognition loop on TNF receptor I, thereby preventing interactions between TNF and its receptor. This TNF antagonist serves as a useful template for developing small molecular inhibitors to prevent inflammatory bone destruction and systemic bone loss in rheumatoid arthritis. This product is for research use only.
- Biologically active peptide
- TNF-α antagonist
- Mimics TNF recognition loop on TNF receptor I
- Prevents interactions of TNF with its receptor
- Useful for developing small molecular inhibitors
- Prevents inflammatory bone destruction in rheumatoid arthritis
- Prevents systemic bone loss in rheumatoid arthritis
Medchemexpress LLC Cyclo(Arg-Pro) TFA | 98.6% | 367.32 | 50 MG
Cyclo(Arg-Pro) TFA is identified as a chitinase inhibitor that impacts cell separation and morphological transitions in yeast by hindering chitinase activity. It specifically prevents cell separation in Saccharomyces cerevisiae, leading to the formation of grape-like cell clusters, without impeding cell growth. Furthermore, it blocks the morphological transition of Candida albicans from its yeast form to its hyphal form, also without inhibiting cell growth.
- Chitinase inhibitor
- Disrupts cell separation in yeast by inhibiting chitinase activity
- Prevents cell separation of Saccharomyces cerevisiae without inhibiting cell growth
- Blocks morphological transition of Candida albicans from yeast to hyphal form without inhibiting cell growth
- For research use only
Medchemexpress LLC Ss47 Tfa | 2636072-62-1 | 99.88% | 1067.09 | 1 MG
SS47 TFA is a PROTAC-based HPK1 degrader that facilitates proteasome-mediated HPK1 degradation. This significantly improves in vivo antitumor efficacy in BCMA CAR-T cell research. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies. SS47 (TFA) is also a click chemistry reagent with an Alkyne group, capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc).
- PROTAC-based HPK1 degrader
- Facilitates proteasome-mediated HPK1 degradation
- Enhances in vivo antitumor efficacy in BCMA CAR-T cell research
- Targets HPK1, an immunosuppressive regulatory kinase
- Click chemistry reagent with alkyne group
- Capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Colivelin TFA | 2803948-60-7 | 99.8% | 2759.12 | 5 MG
Colivelin TFA is a brain-penetrant neuroprotective peptide and a potent activator of STAT3. It suppresses neuronal death in vitro and offers long-term benefits against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. It has potential for treating Alzheimer's disease and ischemic brain injury.
- Suppresses neuronal death and activates neuroprotection through Ca2+/calmodulin-dependent protein kinase IV and STAT3 pathways.
- Reverses caspase3, Bax, and Bcl-2 expressions.
- Increases p-STAT3 protein levels.
- Suppresses spatial working memory impairment and antagonizes hippocampal neuronal loss.
- Improves motor/cognitive function and reduces lesion volume/neurological deficits post-MCAO.
- Protects against cholinotoxin-induced amnesia and ischemic brain injury.
Medchemexpress LLC WP9QY (TFA) | 199999-60-5 | 98.7% | 1340.40 | 25 MG
WP9QY TFA is a biologically active cyclic peptide, serving as a TNF-α Antagonist. It is designed to mimic the critical tumor necrosis factor (TNF) recognition loop on TNF receptor I, preventing interactions of TNF with its receptor. This peptide is a useful template for developing small molecular inhibitors to prevent inflammatory bone destruction and systemic bone loss in rheumatoid arthritis. It is for research use only.
- Biologically active peptide
- TNF-α antagonist
- Mimics critical tumor necrosis factor recognition loop on TNF receptor I
- Prevents TNF interactions with its receptor
- Useful template for small molecular inhibitor development
- Prevents inflammatory bone destruction
- Prevents systemic bone loss in rheumatoid arthritis
- For research use only
Medchemexpress LLC Vasculotide TFA | 1359657-45-6 | 99.7% | 14000 (average) | 25 MG
Vasculotide TFA is an angiopoietin-1 mimetic that functions as a Tie-2 activator, leading to Tie-2 phosphorylation. This compound exhibits anti-inflammatory and anti-permeability effects, making it relevant for various research applications.
- Ameliorates endotoxin-induced endothelial barrier dysfunction
- Promotes angiogenesis in a mouse model of diabetic ulcer
- Protects mice from vascular leakage
- Reduces mortality in murine abdominal sepsis
- Decreases microvascular leakage
- Improves microcirculatory perfusion in a rat model of hemorrhagic shock
Medchemexpress LLC TAM557 TFA | 98.5% | 1119.34 | 1 MG
TAM557 TFA is a cytotoxic tubulysin compound designed for conjugation to transport vehicles such as proteins, peptides, small molecules, or polymeric carriers that incorporate a targeting principle. It is intended for research use only.
- Cytotoxic tubulysin compound
- Modified for conjugation to transport vehicles
- Appearance: solid, white to off-white
- Shipping at room temperature
- Store at -20°C, sealed, away from moisture and light
- In solvent, store at -80°C for 6 months or -20°C for 1 month